UCSF NMR13CBeFBE?jIEyE#!EE!WD9lE}ŢE9>D$5E[E9zEd,DORE2Ŧĉ%EѿaD4#F1 &E"&3pEPzEbRŅE$E:M9DF;|-EŰE@ҮEmEE3JDEErţcE jC1[EERҚD΃EֵŠŲP@N\JbE'Dd,EI՘Ex:FDj ;ŨEi3E1EGA,EѮzEuEF(zJfF8Fg0y[;FkF3fxEEMOtXİV]e{ƈsEAEC;EBF7Fq6F3ƀ\AD#.{|&F$E4D*vm|%b ZE}1E0EdȨDHf4ZEF6VƱF&+EĖl Á,C/xƶDF3!DuE|i+EtE0lF;_DADĕbNū)EwE%E'&D@|Ţ&DC!D=/"FIdE+ebEGşWFKŠzE D.^bF ž(F1 Nyq'qDG,D@EED āf!ƎŽBEVF ХEt[EZCoD;^E_F+KE%jōjaQPZt<ş C@F4DWFF$ňZdE|Da*DEE FSE*4IE `D`ֵNF2EEWc\Fƥ+śEǠqDŮ@Ţ| ~](P,Fb\Ekţs -wi;TEޫlK:EPEhyEr&ØCXDF]8EnЗEdΉEMKxłH{Cl%EVы -$DִE) "KZE0]O|Ʃ"ŦxcX:E"f0DXUuFDf.ķDEND4EFs~ݡFDGTDjaF-FFIDEE>ŖaEF:EnDsRĂOEof;F]'F(JZDkf @iE'gEƃ' բTs-pG z8A jÇ5PDn}ltE(&F E|D[NŊerF*F_-E/k,DIEhC(cEx`F.@BЊEEQq^FEkxEoE2wE(rE.F2/$FEFd虉CŦPp]EC L]lŔk[ƀĬ2ƀjXF^C$qF{E>pE(EvśTDM|CTB[@`EsBFR*iTFvgFP&PŀF$NEow;CF>F<|DF2=EFE?@żlE2FE(|Exk6 y OEÁQcER]E+HOE8[FwGE|Nq~UE̓8` 1sz`EEeÑ4EwGFUJ'9DlKA ŞHDCdEcōƓ}WĮK)E F/AEVF3ű%`:S 4EkŶ!FD'8FP- E4Va[4{(R\F9ĝO)sC'gç&oDgĭMH9%+uŀ/cE5E[E08ECDsEx^x*w&E'F#OETDPpŅ^0ŝRgsc8lFȚh,NExb% DoDuZEBiEID5XDKFm0dƉcťDu?`F gŁ{ŀ8*E"^gŃOF GEěb9ģEF}EnДEmE{FE+D^F+C CŏFQ>Eg-+ D(Fm#>cVE!uFJ*6oE ؞ED7 TFIEw;žzŀEeD/FEdFNDOEFhELED`A0 Ăt8CL\FJQŠE,>F%ŔaFtoExO_F5E+DٖA!ElCĬ1ŐŌU?F0DBdbE^F6CX h2ŪհED3EOi)DxNFExD$0UD6C]L.?@DMDcKE¿E EC:HV`BDD3FEȒE^'F6/sD-EZ'Ť3GEEPeŚE\E2uDœsĤD0HEŜEwDHZFEBEh DsFP(wX'oCG0F^E9@END{^CXgĤŷ }YyDEɋED+V"^F>CD$î=;ĄTFki(]Eԍ9jŴe9f3:F#\DGƘ[œ;AAGFcE4EI-NĀ}EU~EşFE_ߩİ`Š`ʼn*C3$TE4D_z ]E'́F0Ŝ$E<ZŊFl EŁy5G iDłn~iEnF_bE6+и紎 3Dàƀ,bŢHơEڒEz͵EEhEEc;1&~D!XE7l1wQʼn*D[oFwF'`gj;AW8.F 6F ƘjD"E^EL;rF%-vE'iENE6z"gDFEŝF=-Ÿ$5QPzY,:@F+ZN}F <PŦODUƘběEvDSęŀE]klćF[EDC[`ś9*F,D -XgDT{ħ>ƋTFvF2gC•wbF=F?Eki:FE\Γ#rlEZDNtFEBd@|vFbEƆdţF\\pCqOFPoEhdbņ_dL:D! TE[EȄEN\DjFbSZſyBč*EyM~cøM0ECDJ/`FE2Eţ=~F= 3!ME\Aƍ(nBFEkypF6/F &F7 շND_sqDT*F|=y#0G;EEF3tvEoUu#EO3hE 26Ũ+xEF'0F dXlfƉ0Ɔe[>F; CXh(ۆFDu|EE57IrEE+f#2FV.E|\ϢćXEV.OEľF|PE2ẕ̇EsŗDR#eQEA52E^&x &/9 ĉ2p$FwG"?:6mOE bFuř]E-EhbWNF2\F\M8ţ'F1fDkFE:KEETDDCEEE> gFD(E"|wƃF ſ?ҜsNdĽH;lF?EۡZQe-ŮbFƃœBEeE9EDJEc@E F[.Ec,6DnGE%GƀUFr"D>6DDD@DWOE>Rź$,F!RDp\ܗCEKE26 }EŒD,%E~~{xDFWCtEO% DFџFHm9œFF7F9eD$D|BI`ED9ܾF7EQ?(NF;8{FFDĜ`t|UFFlvb DuDĨjńEF%wE9F-uCX'd`E?DҜE*ėEqDzDƟhm|DEŞ%Z]xED@/ޑEJhFR(F\F=ZzZ٫ĸN)E4BF#ømE?˒ŜWDEF<8Ň|ţVD(8wş͋C FWFd_Ō8ŪEڰF#Ē HFM)e$T%F SřݟE@|EbEe<Ŋ(`5E2iF VE{EFͦE-^F89E ESódzEHƃ!rDh0<ďuF+F]EhF }kEƞſDrDJ& OEX ũ$EfE7SDEGȒ$DEc0,Ĕ%_ EDoE'CԪ 1 EAWEŨED/r $+!FR6E5ExEFE$DFF"DƓ-DwD;BE`č~Zt{nE1:EvEBEE~Ƙ`švFeNCE Er3EO&fŮBF]EIſ?E:o4EƄżzdE6EΟĭwAŔF| $E.!E*FĿņ CxƳĠEtE YD~8PDdE .9%EDUAF^FIȒE%D#7ŭvd~Er0AEŤD;ġ<ŽxDyESgKuFMXÏHUFEh\#XFžhtFu$%ixe6E;E AF69sŝ,SCOXEF ŻyDTŃ9=HFQ>ƕ; ;bPFm&E43n ğED :E]LlF-FFc E;C3}ŃE2Es1|CGF5ŔFGyV?t$_F/ukŠu=EEEnZX=U^ŏŨP^EY0ŏ>D42EIEV÷`dEEVHþiBEb~E"E*DQrE1'*T6D/O"F /W!!EE¬FPŕxFdp'EtK`Eɮߚ Eb0 DyDQĊ[EN{ʾXd<5E:FKڷFtıg0 D&ŔF ]!NF;EE>/xv F ]}DEnoFDTU^UBEoEGF+E?_]ZKF rF/&gE/{ȅMO8DE EőEEWYF8^D>ŴHTNF5Ep3 F-v;3EzāC4EW,FWDFEqWE@=Ca7cEH:YAnEٕD)|E[ŶzZЀ0?+6C,fE^ƖFHE3*ĺ/yēYE֟c&Y٢:Ņci…) i{qBz|EEF0Yv# E؊ŀ)E9'J]FmE͌FAR^+EvFB@Fp9ErWFFEŇkŃebEj$Fxź]h=Eũ,VEDJFũJ:"©pE棢D6^?ŲgDſ k޸:^ŶE1cTEĤ]\EyF"SDBEd2Ũ\RƙE&F(aŝCވ)*aaFCFCE'bE[ElWSEO#E-E?EFLDEP %įdE,tsBEX GIȷF*DćDS֘EU&Ö7{E:E7EFKܚE@4prF 6iŃ9H[Aa*.vŮ(EEfEIhEnP`ʼn |LE{EY:FTFE%NZƔErF'<)ű6E6E,6Ć_ nE=/D4 SĂ DWiT]E#EVF!*C˕ƗIFCdE"EN۳JE4FLԉE8F AF+3EݮDܹ3ŋ;EɏZEQ81/ZEGDeřS\Ֆ) ESŘݲEF GdCQĉEEER34ENFBE.d?NF3DXgtDEهD[E6REFKF8%EEŃEı ļi:Ĥa&) F tPD;5aD8_0E6IŞZEPYCS!žDRPeitŔŋE[BěͣřN\E ;E"DRElEsđBE`ӺF!rj4F$LZf5ErEEWFA6Ffň ERE.]EC/ŸŁEDcFNEłE;Rż@DXOEf ,tE7RhFP *{QDF36ADrrEWF|NDdFuFƟVF޳EO0]D?)r7ExWE6E8ŜdE6ĻwYF(AHPFY$EtC wd DVC4%F[hD~FPf@CEGF(qVEEF0F'=F$̅^E*Z"Enf;@ECE6FM\^D,Űyʹ SnDLaDFgŷEIJFd%EBDǡlh7őELJKF ŃE>1E-zŜ>EE\ŤcE%gŘ\C ŔFSFF'ΞE|Y?E<|E.5EhF!CD:0nBӪpFK31$LE[wM"D?\>E'CZŜbņ4sEBZŅaD7EEosPċ< wWEjDEv7XD2*ł{FSF|=Yƞ,*E 4bD /E!XF\*Důe9Ɓ EĶfFҜŖrDm^fF 8j30E1'EEFF _/fE+bD& FoƤELEEEBEHE'((ŅhDDpsD 3yEXnE3ÍـE Et1AE[|EEDHĔx7*EN>į#iDRE#gE3*A=gYLů9FO HEF/ũvEř<)DEf3AD~DFHʼn3DvĠEYDDFj F11NDKESE#lEENE178FłFOjK|DґDFʵťEbFH 7ۀCv=HWF;5F/oFÍXŎZnľF4(C4ńIF hPrDN*CYňEIQeҴDfĶDđqCChF6]EWÐſE$zFF7x(QdD\uŒ+EZf2nJ4GSgF 8Enm8/RaF/JEjB=@Ē]dl ij`CCpCTEE.f+͗w -DęFEE[SD0,Ʀ_`E&43#ŀE|ƑEstEJE"`E@oF*EơEilPDiEjF,F RF[OoDDE o4DBmFu]]9LgmE}.ENFEŸGFbREnSNFN*N;F|Dy HE/LsA@/E=tmI$DH[yĢ|FE)8=E{[FWF9$DHŞŧF^ERĵZE4wY+hEhIĺEۅ&=zDhFQ"Fr1/%)O5 )śtAʼn7F/ŜD7 9?E}F!ţA zZ^D=ń]ZB1_EmE F6"ŕzDEƁ^E8HEhEQF56:E F8Ň ƇŴD[D~Ŷi &EwAġOF29 iE,D5zčaDаDIfFM6EooY ELEŽb CxDT4$EE~ u DBCW Xs>x4DDŢhKF*ŜfFg ƃlE`rŬ E4ZEzEB6<FZGM2ž_::Xv0T jEkFQb&FVrġƑ)ÒmDE-/FőŬ EzCőBVYũoFD"ő't>I9RAJqŬ;EۑF9nbEErŗG$Y|EZtq%PŅNsR ͜Ɵ_wFGȊYRECEC&"UE*ņ`\FyjDBxE@eF&XDe?EaE%U[lţE WE_5E^,E{ŘrLŜD`8+vEuBjFU{]E̓E|(t&E@6EzsKl E?rF~PF F7@BTHOŁA7M!E lzF+DcU[j lŘE.*nEoqDfE84DסĨyDBrDH?lCDVc.ôF$ECOFRXqFJGEF4`*8NÖ:F 9F6 MŒzhE獹EE]sE4EKbEśDŃJEE;Ũ1}EնFzp[zũC*_=F1dK& "B͘FÅL2HF/F ¿,pF*g#zXEEh8!8F*B"E"T@F)9F~}EŻE>rEspE&FŞfE ]EEۆߌ`ņDFų=m ÇF+.$ׁUF9ZG;eFIE"&DŽ|NExF@JsQħFD%wPE7E_R%vWEr֤XFū&F0UFfFjF /E dڙE32HEE ŰrEdeFP#w:DeTE?ExŴ"fEr,êcF F6wEg|WsCx{hTD;DAT E>?0. ƌ'tXFjIF dE=:\ECxF!o EF ZY FBM@ă$F/FED:=Dzh uZVڃK E8F KPŋ$FOFEEDEzFNE}E"C5A#EyŖEv+=D&F YEĘ#V EWE>DM:FFFeF~Fд ąłZ=E>DŎ)F[mERF$DķHc 20ŁTF sŗ*Q'FEf&F<.E_uGF4wŮדF]ZF-FߣųuFE(! h3E p+E?Cj@˫F߉wRD)-F'ŢrE#nĸ7EFCFFE +E ~Gl/CD0Fżxċa ElPQ2E0>8X-DӊED!E'E 7Lf=Ey!Jz D(AEeY$E袵NyďaE:ĭŲEAŶ[ř[F lnm, F(pF6?:EwsŰE%)D݅`6udEEʕC ĂFGqךQ8En.]DEP}C EFŢ"DFuF+9/E&EAEEŻ+ZX. D EuŗF ,p0埐º`DrF:j{i*E9D֞TCڪD`( $LD/hI"i8WEt5hŎ&6ŬƐxF<ōY/*gվXEFTDHD4EEQpfgF1oEKŒF=CyE+F4" E DeWVF`(E̔=F7EC`[XődxKgF4f%)E3]RF ;p*:NVr1iPEl(ij9]Śŗq-1-EEaYC:ſDtK6C| $E@|F8F%/CGEy%DЧcEX?EF.ŋŸ7wC@$jŞдEUe?ĮDO-ŪE~E4:*1ŶrņDf*0Ų3DE{bF (;+{DtįD4FB;Ũųd zDLuBʼnF"pAfFQ'E3žUż D[qEռĂƭzD!E sĺD70BFCME;D~ <~EFnD%:~E5E>ۯ0eEkhhEO|EBkW%ˆGX>lĞM|ƅ]NDupF:{FM\KpFYEm[F uBE"$bZ.V{UYŚWč8@COWp])EF CLD\NEJtER;PaE%)|F$W'EfhD?hDDunEpҵdF'FȕEӦNC:?Ė]F:FKj㟒OҪE(9k֒EGE'F Em2EO3E`]DVE\FME7 h{-D,J`Ħc%ؠ# .`DLtŊF!-@D-06ŀ#nFFcD1EFmEwE3pĝ`mCpEgFDĚwB+JEh4%\@FĐ%FE.HFoE%sF$DDŌcE"p&FvĊbm!zcElEEmġ]#9EJFV6C$[XF R-E1uK)ESUAIő,ɪE6FcE(bD @Ev˭E@LDF0ołѮ ^bX$pEd@* Ó ĎKFVW/z$AƟDlű|3[.FF @% "FCEL!&FDT'_LCTĊ[Ơ}(Ū@`&3E1QF%8@]6 B;BxŪ^c5yzD[WE*'#FdūDJŕF,9% nƕT;ŗFtA GhjF3uD饍4E֮ƂFO6dE?FFD8RPq EcFr'4%Ŏ]$D r`WE~ wuF*4Ɓ#OŷOgvEm"F?t5E*e{EF:.EI,#E ANBSD[E4\ēKE޺4F DE .kE,wECmyenj_pjEŻEpKKvQI.EnkHuFP